[CAS NO. 1005883-72-6] Z433927330
PRODUCTS SPECIFICATIONS [1005883-72-6]
DESCRIPTION [1005883-72-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 364.40 |
| Molecular Formula | C20H20N4O3 |
| SMILES | O=C(OCC)C1=CC=C(NC(NCC2=CC=C(N3N=CC=C3)C=C2)=O)C=C1 |
Summary
Z433927330 is a potent and selective inhibitor of Aquaporin-7 (AQP7) , less potently inhibits AQP3 and AQPs9 , with IC 50 s of ~0.2 µM, ~0.7 µM and ~1.1 µM for mAQP7, mAQP3 and mAQP9, respectively [1] .
IC50 & Target
IC50: ~0.2 µM (mAQP7), ~0.7 µM (mAQP3), ~1.1 µM (mAQP9) [1]
In Vitro
Z433927330 inhibits glycerol permeability, with an IC 50 of ~0.6 µM [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 280 mg/mL ( 768.39 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.7442 mL | 13.7212 mL | 27.4424 mL |
| 5 mM | 0.5488 mL | 2.7442 mL | 5.4885 mL |
| 10 mM | 0.2744 mL | 1.3721 mL | 2.7442 mL |
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1.
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2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.33 mg/mL (6.39 mM); Clear solution