[CAS NO. 100957-85-5] SORT-PGRNinteractioninhibitor1

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [100957-85-5]

Catalog

HY-115213

Brand

MCE

CAS

100957-85-5

DESCRIPTION [100957-85-5]

Overview

MDL	MFCD02090479
Molecular Weight	258.32
Molecular Formula	C15H18N2O2
SMILES	O=C(C1=CC(C(C)(C)C)=NN1CC2=CC=CC=C2)O

For research use only. We do not sell to patients.

Summary

SORT-PGRN interaction inhibitor 1 is a potent inhibitor of the sortilin-progranulin interaction with an IC ₅₀ of 2 μM ^[1] .

IC50 & Target

IC50: 2 μM (Sortilin-progranulin interaction) ^[1]

In Vitro

SORT-PGRN interaction inhibitor 1 (Compound 2) with sufficient potency and physicochemical properties to enable co-crystallization with sortilin ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 387.12 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.8712 mL	19.3558 mL	38.7117 mL
5 mM	0.7742 mL	3.8712 mL	7.7423 mL
10 mM	0.3871 mL	1.9356 mL	3.8712 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (9.68 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (9.68 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (9.68 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Shawn J Stachel, et al. Identification of potent inhibitors of the sortilin-progranulin interaction. Bioorg Med Chem Lett. 2020 Sep 1;30(17):127403.