[CAS NO. 1016456-76-0] EZ-482
PRODUCTS SPECIFICATIONS [1016456-76-0]
DESCRIPTION [1016456-76-0]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 498.94 |
| Molecular Formula | C23H19ClN4O5S |
| SMILES | O=C(NC1=CC(S(=O)(NC2=CC=CC(Cl)=C2)=O)=CC=C1O)CC3=NN(C)C(C4=C3C=CC=C4)=O |
Summary
EZ-482, a novel ligand of apolipoprotein (apoE) , binds to sites on apoE in the C-terminal domain with K d s of 5-10 μM for apoE3 and apoE4. EZ-482 binds to apoE4 by a unique N-terminal allosteric effect. EZ482 has the potential for Alzheimer’s diseas [1] .
IC50 & Target
Kd: 5-10 μM (apoE3 and apoE4) [1]
In Vitro
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 83.33 mg/mL ( 167.01 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.0042 mL | 10.0212 mL | 20.0425 mL |
| 5 mM | 0.4008 mL | 2.0042 mL | 4.0085 mL |
| 10 mM | 0.2004 mL | 1.0021 mL | 2.0042 mL |
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1.
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2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.08 mg/mL (4.17 mM); Clear solution