[CAS NO. 10212-20-1] 2'-Deoxy-2'-fluorocytidine
PRODUCTS SPECIFICATIONS [10212-20-1]
DESCRIPTION [10212-20-1]
Overview
| MDL | MFCD00057445 |
|---|---|
| Molecular Weight | 245.21 |
| Molecular Formula | C9H12FN3O4 |
| SMILES | O[C@H]1[C@@H](F)[C@H](N2C(N=C(N)C=C2)=O)O[C@@H]1CO |
1 Publications Citing Use of MCE
Summary
2'-Deoxy-2'-fluorocytidine, an nucleoside analog, is a potent inhibitor of
Crimean-Congo hemorrhagic fever virus (CCHFV)
replication. 2′-deoxy-2′-fluorocytidine can act synergistically with T705 to increase the potency of both compounds antiviral effects on CCHFV replication
[1]
.
In Vitro
2'-Deoxy-2'-fluorocytidine has antiviral activities, showing 50% effective concentrations (EC 50 ) of 61 nM and 31 nM against CCHFV and CCHFV/ZsG in Huh7 cells, respectively. And it shows a 50% cytotoxicity concentration (CC 50 ) of >50.0 μM in Huh7 cells [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
H 2 O : 5 mg/mL ( 20.39 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 4.0781 mL | 20.3907 mL | 40.7814 mL |
| 5 mM | 0.8156 mL | 4.0781 mL | 8.1563 mL |
| 10 mM | 0.4078 mL | 2.0391 mL | 4.0781 mL |
-
1.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (407.81 mM); Clear solution; Need ultrasonic
Synonyms