[CAS NO. 102195-79-9] N-Boc-4-hydroxy-L-proline methyl ester
PRODUCTS SPECIFICATIONS [102195-79-9]
DESCRIPTION [102195-79-9]
Overview
| MDL | MFCD00237541 |
|---|---|
| Molecular Weight | 245.27 |
| Molecular Formula | C11H19NO5 |
| SMILES | O=C(N1[C@H](C(OC)=O)C[C@H](O)C1)OC(C)(C)C |
Summary
N-Boc-cis-4-hydroxy-L-proline methyl ester is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . N-Boc-cis-4-hydroxy-L-proline methyl ester is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs [1] [2
IC50 & Target
|
Non-cleavable |
In Vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker
[1]
.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
References