[CAS NO. 10299-44-2] 8-Azaadenosine

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PRODUCTS SPECIFICATIONS [10299-44-2]

Catalog

HY-115686

Brand

MCE

CAS

10299-44-2

DESCRIPTION [10299-44-2]

Overview

MDL	MFCD01631207
Molecular Weight	268.23
Molecular Formula	C9H12N6O4
SMILES	NC1=NC=NC2=C1N=NN2[C@@H]3O[C@@H]([C@H]([C@H]3O)O)CO

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]J Cancer. 2021; 12(24):7334-7348.

Summary

8-Azaadenosine is a potent ADAR1 inhibitor and an A-to-I editing inhibitor. 8-Azaadenosine blocks RNA editing and inhibits proliferation, 3D growth, invasion, and migration in thyroid cancer cells ^[1] ^[2] .

In Vitro

8-Azaadenosine targets ADAR (adenosine deaminases acting on double-stranded RNA) activity only and does not affect ADAR1 mRNA levels ^[1] ^[2] .
8-Azaadenosine (10-25 nM) restores let-7 miRNA biogenesis commensurate with a reduction in ADAR1 expression, RNA editing activity and LIN28B expression in JAK2/BCR-ABL1 transduced progenitors after two weeks in stromal co-culture ^[1] .
8-Azaadenosine (10, 100 nM) shows no effect on BCR-ABL and JAK2 signaling, as demonstrated by qRT-PCR analysis and p-CRKL and p-STAT5a Western blot analysis ^[1] .
8-Azaadenosine (0.1, 0.5, 1, 2 µM; 5 days) decreases cell viability/proliferation in a dose-dependent manner in TPC1 and Cal62 cells ^[2] .
8-Azaadenosine (1, 2 µM; 16 hours) impedes invasion and migration of TPC1 and Cal62 cells ^[2] .
8-Azaadenosine (1, 2 µM) inhibits the editing activity in TPC1 and Cal62 cells. By contrast, ADAR1 mRNA levels remains stable in both cells lines ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL ( 932.04 mM ; Need ultrasonic)

H ₂ O : 3.33 mg/mL ( 12.41 mM ; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7281 mL	18.6407 mL	37.2814 mL
5 mM	0.7456 mL	3.7281 mL	7.4563 mL
10 mM	0.3728 mL	1.8641 mL	3.7281 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (7.75 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (7.75 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (7.75 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

3H-1,2,3-Triazolo[4,5-d]pyrimidin-7-amine, 3-β-D-ribofuranosyl-

3H-v-Triazolo[4,5-d]pyrimidine, 7-amino-3-β-D-ribofuranosyl-

3-β-D-Ribofuranosyl-3H-1,2,3-triazolo[4,5-d]pyrimidin-7-amine

8-Azaadenosine

7-Amino-3-β-D-ribofuranosyl-v-triazolo[4,5-d]pyrimidine

NSC 72961