[CAS NO. 1043495-96-0] RO5256390
PRODUCTS SPECIFICATIONS [1043495-96-0]
DESCRIPTION [1043495-96-0]
Overview
| MDL | MFCD28405494 |
|---|---|
| Molecular Weight | 218.29 |
| Molecular Formula | C13H18N2O |
| SMILES | NC1=N[C@@H](C[C@@H](C2=CC=CC=C2)CC)CO1 |
Summary
RO5256390 is an agonist of trace amine-associated receptor 1 ( TAAR1 ), a highly conserved G-protein-coupled receptor (GPCR) bound by endogenous trace amines. RO5256390 can be used to reduce multiple behavioral effects of drugs of abuse through their actions on the mesocorticolimbic system [1] . RO5256390 is a modulator of monoaminergic neurotransmission, blocks psychostimulant-induced hyperactivity and produces a brain activation pattern reminiscent of the antipsychotic drug olanzapine, suggesting antipsychotic-like properties [2] .
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 50 mg/mL ( 229.05 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 4.5811 mL | 22.9053 mL | 45.8106 mL |
| 5 mM | 0.9162 mL | 4.5811 mL | 9.1621 mL |
| 10 mM | 0.4581 mL | 2.2905 mL | 4.5811 mL |
References
- [1] Ferragud A, et al. The Trace Amine-Associated Receptor 1 Agonist RO5256390 Blocks Compulsive, Binge-like Eating in Rats. Neuropsychopharmacology. 2017 Jun;42(7):1458-1470.
- [2] Revel FG, et al. A new perspective for schizophrenia: TAAR1 agonists reveal antipsychotic- and antidepressant-like activity, improve cognition and control body weight. Mol Psychiatry. 2013 May;18(5):543-56.