[CAS NO. 105118-14-7] Datelliptium chloride
PRODUCTS SPECIFICATIONS [105118-14-7]
DESCRIPTION [105118-14-7]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 397.94 |
| Molecular Formula | C23H28ClN3O |
| SMILES | CC1=C2C(NC3=C2C=C(O)C=C3)=C(C)C4=CC=[N+](CCN(CC)CC)C=C41.[Cl-] |
Summary
Datelliptium chloride is a DNA-intercalating agent derived from ellipticine, with anti-tumor activities.
In Vitro
Datelliptium (100 μM) shows significantly cytotoxic effects after 2 hr of treatment in suspension and primary cultures of rat hepatocytes. Datelliptium mobilizes glycogen in both rat systems in vitro concentration dependently. The half-maximal effect is 14.3 μM in isolated hepatocytes, whereas in cultured rat hepatocytes it is 5.9 μM. Datelliptium also leads to a concentration-dependent decrease in gluconeogenesis from lactate in cells [1] . Datelliptium acetate is selectively cytotoxic for solid tumors over leukemia L1210. Human tumors H-125 and HCT-116 demonstrates less sensitivity to datelliptium acetate [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Upon intravenous administration, datelliptium acetate shows potent inhibitory activities in vivo against a variety of murine solid tumors. Datelliptium acetate is highly active against early-stage colon #38 with highest non-toxic dose (HNTD) of 170 mg/kg TD, and weight loss of 10%, T/C of 0% [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H 2 O : 41.67 mg/mL ( 104.71 mM ; Need ultrasonic)
DMSO : 5 mg/mL ( 12.56 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.5129 mL | 12.5647 mL | 25.1294 mL |
| 5 mM | 0.5026 mL | 2.5129 mL | 5.0259 mL |
| 10 mM | 0.2513 mL | 1.2565 mL | 2.5129 mL |
References
- [1] Donato MT, et al. Toxicity of the antitumoral drug datelliptium in hepatic cells: Use of models in vitro for the prediction of toxicity in vivo. Toxicol In Vitro. 1992 Jul;6(4):295-302.
- [2] Mucci-LoRusso P, et al. Activity of datelliptium acetate (NSC 311152; SR 95156A) against solid tumors of mice. Invest New Drugs. 1990 Aug;8(3):253-61.