[CAS NO. 1055412-47-9] (Z)-SU5614

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PRODUCTS SPECIFICATIONS [1055412-47-9]

Catalog

HY-18952A

Brand

MCE

CAS

1055412-47-9

DESCRIPTION [1055412-47-9]

Overview

MDL	MFCD08443928
Molecular Weight	272.73
Molecular Formula	C15H13ClN2O
SMILES	O=C1NC2=C(C=C(Cl)C=C2)/C1=C/C3=C(C)C=C(C)N3

For research use only. We do not sell to patients.

Summary

(Z)-SU5614 is a potent FLT3 inhibitor and selectively induces growth arrest, apoptosis , and cell cycle arrest in Ba/F3 and AML cell lines expressing a constitutively activated FLT3 ^[1] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 16.67 mg/mL ( 61.12 mM ; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.6666 mL	18.3331 mL	36.6663 mL
5 mM	0.7333 mL	3.6666 mL	7.3333 mL
10 mM	0.3667 mL	1.8333 mL	3.6666 mL

* Please refer to the solubility information to select the appropriate solvent.

References

[1] Spiekermann K, et al. The protein tyrosine kinase inhibitor SU5614 inhibits FLT3 and induces growth arrest and apoptosis in AML-derived cell lines expressing a constitutively activated FLT3. Blood. 2003 Feb 15;101(4):1494-504.