[CAS NO. 1062648-63-8] DMT1blocker2
PRODUCTS SPECIFICATIONS [1062648-63-8]
DESCRIPTION [1062648-63-8]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 263.29 |
| Molecular Formula | C16H13N3O |
| SMILES | OC1=C2C3=C(C=CC=C3)CCC2=NN1C4=NC=CC=C4 |
Summary
DMT1 blocker 2 is a direct inhibitor of divalent metal transporter 1 ( DMT1 ), with an IC 50 of 0.83 μM. DMT1 blocker 2 can block iron uptake by enterocytes in vivo [1] .
IC50 & Target
IC50: 0.83 μM (divalent metal transporter 1) [1]
In Vitro
In Vivo
DMT1 blocker 2 (50 mg/kg; p.o.) blocks iron uptake by enterocytes in an acute rat model of iron hyperabsorption [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Weanling (3-4 weeks) rats were placed on a low iron diet for four weeks [1] |
| Dosage: | 50 mg/kg |
| Administration: | Oral gavage followed 1 h later by an iron challenge |
| Result: | Attenuated the post-challenge serum iron increase. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 50 mg/mL ( 189.90 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.7981 mL | 18.9905 mL | 37.9809 mL |
| 5 mM | 0.7596 mL | 3.7981 mL | 7.5962 mL |
| 10 mM | 0.3798 mL | 1.8990 mL | 3.7981 mL |