[CAS NO. 1067647-43-1] ELOVL6-IN-2

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PRODUCTS SPECIFICATIONS [1067647-43-1]

Catalog

HY-12146

Brand

MCE

CAS

1067647-43-1

DESCRIPTION [1067647-43-1]

Overview

MDL	MFCD18782631
Molecular Weight	579.49
Molecular Formula	C28H23F6N3O4
SMILES	O=C1N(C2=CC=CC=C2)C3=C(C(CC(C)(C)C3)=O)C1(C4=C(C)NN(C5=CC=C(OC(F)(F)F)C=C5)C4=O)C(F)(F)F

For research use only. We do not sell to patients.

Summary

ELOVL6-IN-2 is a potent, orally active and selective ELOVL6 inhibitor. ELOVL6-IN-2 inhibits mouse ELOVL6 activities, with an IC ₅₀ value of 34 nM ^[1] .

IC50 & Target

IC50: 34 nM (ELOVL6) ^[1]

In Vivo

ELOVL6-IN-2 (0.1~1mg/kg; p.o.; 2 hours) potently and dose-proportionally suppresses the elongation index in the liver ^[1] .
ELOVL6-IN-2 (10mg/kg; p.o.; 2 hours) demonstrates highly liver penetrable ^[1] .
ELOVL6-IN-2 (1mg/kg; p.o.; 2~24 hours) exhibits sustained plasma exposure ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male C57BL/6J mice
Dosage:	0.1~1mg/kg
Administration:	P.o
Result:	Potently and dose-proportionally suppressed the elongation index in the liver.

Animal Model:	Male C57BL/6J mice
Dosage:	10 mg/kg
Administration:	P.o
Result:	Demonstrated highly liver penetrable.

Animal Model:	Male C57BL/6J mice
Dosage:	1 mg/kg
Administration:	P.o
Result:	Exhibited sustained plasma exposure.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 172.57 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7257 mL	8.6283 mL	17.2566 mL
5 mM	0.3451 mL	1.7257 mL	3.4513 mL
10 mM	0.1726 mL	0.8628 mL	1.7257 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: 2.5 mg/mL (4.31 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (4.31 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] akahashi T, et al. Synthesis and evaluation of a novel indoledione class of long chain fatty acid elongase 6 (ELOVL6) inhibitors. J Med Chem. 2009;52(10):3142-3145.