[CAS NO. 107355-45-3] WIN 54954

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PRODUCTS SPECIFICATIONS [107355-45-3]

Catalog

HY-106296

Brand

MCE

CAS

107355-45-3

DESCRIPTION [107355-45-3]

Overview

MDL	-
Molecular Weight	383.27
Molecular Formula	C18H20Cl2N2O3
SMILES	ClC1=C(OCCCCCC2=CC(C)=NO2)C(Cl)=CC(C3=NCCO3)=C1

For research use only. We do not sell to patients.

Summary

WIN 54954 is an orally active and broad-spectrum antipicornavirus agent. WIN 54954 is effectiveness against human rhinovirus, echovirus 9 and enterovirus infections ^[1] ^[2] .

In Vitro

WIN 54954 reduces plaque formation of 50 of 52 rhinovirus serotypes (MICs ranges from 0.007 to 2.2 μg/mL) ^[1] . WIN 54954 inhibits 15 commonly isolated enteroviruses, with an EC ₈₀ of 0.06 μg/mL ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

WIN 54954 (2-100 mg/kg; p.o.) protects 50% of the mice from developing paralysis following infection with coxsackievirus A-9 and echovirus-9 at the dose of 2 and 100 mg/kg, respectively ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 260.91 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6091 mL	13.0456 mL	26.0913 mL
5 mM	0.5218 mL	2.6091 mL	5.2183 mL
10 mM	0.2609 mL	1.3046 mL	2.6091 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (6.52 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (6.52 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (6.52 mM); Clear solution

* All of the co-solvents are available by MCE.