[CAS NO. 1093070-14-4] PLproinhibitor
PRODUCTS SPECIFICATIONS [1093070-14-4]
DESCRIPTION [1093070-14-4]
Overview
| MDL | MFCD12547684 |
|---|---|
| Molecular Weight | 346.42 |
| Molecular Formula | C22H22N2O2 |
| SMILES | O=C(C1=CC(NC(C)=O)=CC=C1C)N[C@H](C)C2=C(C=CC=C3)C3=CC=C2 |
6 Publications Citing Use of MCE
Summary
PLpro inhibitor is a potent inhibitor of papain-like protease (PLpro) with an IC 50 of 2.6 µM [1] . PLpro inhibitor inhibits SARS-CoV-2 PLpro with an IC 50 of 5.0 µM and an EC 50 of 21.0 µM [2] .
IC50 & Target
In Vitro
PLpro inhibitor is a potent inhibitor against the papain-like protease (PLpro) from the coronavirus that causes severe acute respiratory syndrome (SARS-CoV). PLpro inhibitor was found to have IC 50 value of 2.6 μM. PLpro inhibitor display significant antiviral activity with EC 50 values of 13.1 μM, without toxicity up to the highest concentration tested. Notably, the increasing antiviral potency correlates with the in vitro inhibition of PLpro, suggesting that the compounds work directly on the enzyme in cells [1] [3] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 288.67 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.8867 mL | 14.4333 mL | 28.8667 mL |
| 5 mM | 0.5773 mL | 2.8867 mL | 5.7733 mL |
| 10 mM | 0.2887 mL | 1.4433 mL | 2.8867 mL |
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Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (7.22 mM); Clear solution
References
- [1] Ratia, K., et al., A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication. Proc Natl Acad Sci U S A, 2008. 105(42): p. 16119-24.
- [2] http://www.google.com/patents/WO2010022355A1cl=en
- [3] Brendan T Freitas, et al. Characterization and Noncovalent Inhibition of the Deubiquitinase and deISGylase Activity of SARS-CoV-2 Papain-Like Protease. ACS Infect Dis. 2020 May 19.
Synonyms