[CAS NO. 109351-36-2] Sinococuline
PRODUCTS SPECIFICATIONS [109351-36-2]
DESCRIPTION [109351-36-2]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 333.38 |
| Molecular Formula | C18H23NO5 |
| SMILES | COC1=C([C@]([H])(C2)NCC3)[C@]3(C4=C2C=CC(OC)=C4O)C[C@H](O)[C@@H]1O |
Summary
In Vitro
Sinococuline (0.5-5.0 μg/mL; 6 days) inhibits the non-structural protein-1 (NS1) release by DENV-2 infected Vero cells
[1]
.
Sinococuline (0-40 μg/mL; 48 h) inhibits pan-DENV infection in Vero cells, with IC
50
s of 0.2, 0.08, 0.17, and 0.1 μg/mL for DENV-1, DENV-2, DENV-3, and DENV-4, respectively
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Sinococuline (0.5-2.0 mg/kg/day; i.p. twice a day for 5 days) decreases the morbidity and increases the survival of severely DENV-infected AG129 mice, with no body weight change [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | AG129 mouse (an interferon type I and II receptor-deficient mice) with severe DENV-infection [1] |
| Dosage: | 0.5, 1.0, 2.0 mg/kg/day |
| Administration: | I.p. twice a day for 5 days |
| Result: |
Showed delayed mortality and survived significantly of mice, but none of the mice could survive till the end of experiment at the dose of 0.5 mg/kg/day.
The mice completely survived through the entire course of experiment at the dose of 2.0 mg/kg/day. |
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
References