[CAS NO. 1097917-15-1] ASP3026

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PRODUCTS SPECIFICATIONS [1097917-15-1]

Catalog

HY-13326

Brand

MCE

CAS

1097917-15-1

DESCRIPTION [1097917-15-1]

Overview

MDL	MFCD21609265
Molecular Weight	580.74
Molecular Formula	C29H40N8O3S
SMILES	COC(C=C(N1CCC(N2CCN(C)CC2)CC1)C=C3)=C3NC4=NC=NC(NC5=C(S(C(C)C)(=O)=O)C=CC=C5)=N4

For research use only. We do not sell to patients.

5 Publications Citing Use of MCE

Summary

ASP3026 is a potent, selective and orally active inhibitor of anaplastic lymphoma kinase (ALK) . ASP3026 induces apoptosis of tumor cells. ASP3026 can be used for the research of non-small cell lung cancer (NSCLC) ^[1] ^[2] .

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT01401504	Astellas Pharma Inc	Solid Tumor	May 2011	Phase 1
NCT01284192	Astellas Pharma Inc	Advanced Malignancies\|Positive for Anaplastic Lymphoma Kinase\|Positive for Proto-Oncogene Tyrosine-Protein Kinase ROS\|Solid Tumor\|B-Cell Lymphoma	December 2010	Phase 1

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 20 mg/mL ( 34.44 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7219 mL	8.6097 mL	17.2194 mL
5 mM	0.3444 mL	1.7219 mL	3.4439 mL
10 mM	0.1722 mL	0.8610 mL	1.7219 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2 mg/mL (3.44 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2 mg/mL (3.44 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2 mg/mL (3.44 mM); Clear solution

* All of the co-solvents are available by MCE.