[CAS NO. 110-16-7] Maleic Acid
PRODUCTS SPECIFICATIONS [110-16-7]
DESCRIPTION [110-16-7]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 116.07 |
| Molecular Formula | C4H4O4 |
| SMILES | O=C(O)/C=C\C(O)=O |
Summary
Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of E. coli and L. monocytogenes .
IC50 & Target
|
GAD |
Human Endogenous Metabolite |
In Vitro
The MICs of WT 10403S for the acids (e.g., Maleic Acid) are 34 mM, 25 mM, 31 mM and 30 mM which correspond to pH values prior to growth of 4.84, 5.14, 5.32 and 5.02 respectively. Of all compounds tested, Maleic Acid is the least inhibitory despite acting at a lower pH (4.84). The most acid resistant (10403S) and the weakest (EGD-e) strain are challenged with 8.6 mM and 4.3 mM of each organic acid at pH 3 and 3.3 respectively. On both strains, Maleic Acid is the most bactericidal [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
H 2 O : 100 mg/mL ( 861.55 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 8.6155 mL | 43.0775 mL | 86.1549 mL |
| 5 mM | 1.7231 mL | 8.6155 mL | 17.2310 mL |
| 10 mM | 0.8615 mL | 4.3077 mL | 8.6155 mL |
-
1.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (861.55 mM); Clear solution; Need ultrasonic
References
- [1] Fonda ML, et al. Glutamate decarboxylase. Substrate specificity and inhibition by carboxylic acids. Biochemistry. 1972 Mar 28;11(7):1304-9.
- [2] Paudyal R, et al. A novel approach in acidic disinfection through inhibition of acid resistance mechanisms; Maleic acid-mediated inhibition of glutamate decarboxylase activity enhances acid sensitivity of Listeria monocytogenes. Food Microbiol. 2018 Feb;69:96-104.
Synonyms