[CAS NO. 11041-94-4] Higenamine hydrochloride
PRODUCTS SPECIFICATIONS [11041-94-4]
DESCRIPTION [11041-94-4]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 307.77 |
| Molecular Formula | C16H18ClNO3 |
| SMILES | OC1=CC2=C(C(CC3=CC=C(O)C=C3)NCC2)C=C1O.[H]Cl |
1 Publications Citing Use of MCE
Summary
Higenamine hydrochloride (Norcoclaurine hydrochloride), a β2-AR agonist, is a key component of the Chinese herb aconite root that prescribes for treating symptoms of heart failure in the oriental Asian countries. Higenamine hydrochloride (Norcoclaurine hydrochloride) has anti-apoptotic effects [1] [2] .
IC50 & Target
β2-AR [1]
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT01451229 | Peking Union Medical College Hospital |
Healthy
|
June 2009 | Phase 1 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 100 mg/mL ( 324.92 mM ; Need ultrasonic)
H 2 O : 10 mg/mL ( 32.49 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.2492 mL | 16.2459 mL | 32.4918 mL |
| 5 mM | 0.6498 mL | 3.2492 mL | 6.4984 mL |
| 10 mM | 0.3249 mL | 1.6246 mL | 3.2492 mL |
-
1.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (324.92 mM); Clear solution; Need ultrasonic
-
2.
-
3.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.08 mg/mL (6.76 mM); Clear solution
References
- [1] Wu MP, et al. Higenamine protects ischemia/reperfusion induced cardiac injury and myocyte apoptosis through activation of β2-AR/PI3K/AKT signaling pathway. Pharmacol Res. 2016 Feb;104:115-23.
- [2] Lee SR, et al. Acute oral intake of a higenamine-based dietary supplement increases circulating free fatty acidsand energy expenditure in human subjects. Lipids Health Dis. 2013 Oct 21;12:148.
Synonyms