[CAS NO. 1104874-94-3] MHP

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PRODUCTS SPECIFICATIONS [1104874-94-3]

Catalog

HY-101572

Brand

MCE

CAS

1104874-94-3

DESCRIPTION [1104874-94-3]

Overview

MDL	MFCD31382170
Molecular Weight	293.36
Molecular Formula	C16H23NO4
SMILES	OC(C=C1)=CC=C1C[C@@H](C(OC)=O)NC(CCCCC)=O

For research use only. We do not sell to patients.

Summary

MHP (Methyl caprooyl tyrosinate) is an activator of sphingosine kinase ( SPHK1 ), and significantly stimulates CAMP mRNA and protein production. MHP (Methyl caprooyl tyrosinate) enhances antimicrobial defense and innate immunity ^[1] .

IC50 & Target

SphK1

In Vitro

MHP (50-250 μM for 24 hours) increases CAMP mRNA levels in keratinocytes ^[1] .
MHP (100 μM for 24 hours) increases CAMP protein levels in keratinocytes ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay ^[1]

Cell Line:	Keratinocytes
Concentration:	100 μM
Incubation Time:	24 hours
Result:	Increased CAMP protein levels in keratinocytes.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT03041571	University of Florida	Narrative Medicine\|Chronic Disease\|Terminal Illness\|Cancer\|Diabetes Mellitus\|Cystic Fibrosis\|Rheumatologic Disorder\|Oncologic Disorders\|Hematologic Diseases	March 1, 2017
NCT05542914	Florida State University\|Nexo Asociacion Civil	Substance Abuse\|HIV	December 2022	Not Applicable
NCT04863521	Naima Health LLC\|University of Pittsburgh\|Obstetrix Medical Group	Telemedicine	June 20, 2022	Not Applicable

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL ( 340.88 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.4088 mL	17.0439 mL	34.0878 mL
5 mM	0.6818 mL	3.4088 mL	6.8176 mL
10 mM	0.3409 mL	1.7044 mL	3.4088 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (8.52 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (8.52 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (8.52 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Jeong SK, et al. Sphingosine kinase 1 activation enhances epidermal innate immunity through sphingosine-1-phosphate stimulation of cathelicidin production. J Dermatol Sci. 2015 Sep;79(3):229-34.