[CAS NO. 11078-21-0] Filipin complex

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PRODUCTS SPECIFICATIONS [11078-21-0]

Catalog

HY-N6716

Brand

MCE

CAS

11078-21-0

DESCRIPTION [11078-21-0]

Overview

MDL	-
Molecular Weight	654.80
Molecular Formula	C35H58O11(forFilipinIII)
SMILES	[Filipin complex]

For research use only. We do not sell to patients.

4 Publications Citing Use of MCE

Summary

Filipin complex is a potent broad spectrum 28-membered ring pentaene macrolide antifungal antibiotic . Filipin complex is also a highly fluorescent polyene. Filipin complex specifically binds free cholesterol and is well established as a histochemical marker for the detection of unesterified cellular cholesterol . Filipin complex consists of four analogues (Filipins I-IV), with Filipin III (HY-N6718) comprising the bulk (>70%) of the complex ^[1] ^[2] ^[3] .

IC50 & Target

Macrolide

In Vitro

Filipin complex interacts with membrane sterols causing the alteration of membrane structure ^[2] . For cholesterol staining, cells were incubated with Filipin complex for 2 h ^[3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Source

Streptomyces filipinensis

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL ( 152.72 mM )

Ethanol : 10 mg/mL ( 15.27 mM ; ultrasonic and warming and heat to 60°C)

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5272 mL	7.6359 mL	15.2718 mL
5 mM	0.3054 mL	1.5272 mL	3.0544 mL
10 mM	0.1527 mL	0.7636 mL	1.5272 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (3.82 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (3.82 mM); Clear solution
3.

Add each solvent one by one: 10% EtOH >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (3.82 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

Filipin

Filimarisin

U 5956