[CAS NO. 111-87-5] 1-Octanol
PRODUCTS SPECIFICATIONS [111-87-5]
DESCRIPTION [111-87-5]
Overview
| MDL | MFCD00002988 |
|---|---|
| Molecular Weight | 130.23 |
| Molecular Formula | C8H18O |
| SMILES | OCCCCCCCC |
Summary
IC50 & Target
|
T-type calcium channel |
Microbial Metabolite |
In Vitro
1-octanol inhibits native T-currents at subanesthetic concentrations with an IC 50 of approximately 4 μM. In contrast, 1-octanol is up to 30-fold less potent in inhibiting recombinant Ca V 3.3 T-channels heterologously expressed in human embryonic kidney cells [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT00080366 | National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) |
Essential Tremor
|
March 2004 | Phase 2 |
| NCT00001986 | National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) |
Essential Tremor
|
January 2000 | Phase 1 |
| NCT00102596 | National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) |
Essential Tremor
|
January 2005 | Phase 2 |
| NCT00016679 | National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) |
Essential Tremor
|
May 2001 | Phase 1 |
Appearance
Liquid
Source
Escherichia coli
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Pure form | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 767.87 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 7.6787 mL | 38.3936 mL | 76.7872 mL |
| 5 mM | 1.5357 mL | 7.6787 mL | 15.3574 mL |
| 10 mM | 0.7679 mL | 3.8394 mL | 7.6787 mL |
References
- [1] Joksovic PM, et al. Mechanisms of inhibition of T-type calcium current in the reticular thalamic neurons by 1-octanol: implication of the protein kinase C pathway. Mol Pharmacol. 2010 Jan;77(1):87-94.
- [2] Akhtar MK, et al. Microbial production of 1-octanol: A naturally excreted biofuel with diesel-like properties. Metab Eng Commun. 2014 Nov 13;2:1-5.
Synonyms