[CAS NO. 1118460-77-7] UCPH-101
PRODUCTS SPECIFICATIONS [1118460-77-7]
DESCRIPTION [1118460-77-7]
Overview
| MDL | MFCD12913298 |
|---|---|
| Molecular Weight | 422.48 |
| Molecular Formula | C27H22N2O3 |
| SMILES | O=C(C1)C2=C(OC(N)=C(C#N)C2C3=CC=C(OC)C=C3)CC1C4=CC=CC5=C4C=CC=C5 |
1 Publications Citing Use of MCE
Summary
UCPH-101 is an excitatory amino acid transporter subtype 1 ( EAAT1 ) inhibitor with an IC 50 of 0.66 μM.
IC50 & Target
IC50: 0.66 μM (EAAT1) [1]
In Vitro
UCPH-101 and UCPH-102 inhibit EAAT1 anion currents in a concentration-dependent manner, with K D values of 0.34±0.03 μM (Hill=1.3±0.13, n≥9) for UCPH-101 and 0.17±0.02 μM (Hill=0.97±0.11, n≥7) for UCPH-102. A small but significant decrease in the total expression levels of both HA-EAAT1 and HA-GLAST is observed in cells preincubated with 100 μM UCPH-101 (p=0.048) [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 50 mg/mL ( 118.35 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.3670 mL | 11.8349 mL | 23.6698 mL |
| 5 mM | 0.4734 mL | 2.3670 mL | 4.7340 mL |
| 10 mM | 0.2367 mL | 1.1835 mL | 2.3670 mL |
-
1.