[CAS NO. 1135205-94-5] AWL-II-38.3

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PRODUCTS SPECIFICATIONS [1135205-94-5]

Catalog

HY-18832

Brand

MCE

CAS

1135205-94-5

DESCRIPTION [1135205-94-5]

Overview

MDL	-
Molecular Weight	469.42
Molecular Formula	C23H18F3N5O3
SMILES	O=C(C1=CC=NO1)NC2=CC(NC(C3=CC(C(F)(F)F)=CC(N4C=NC(C)=C4)=C3)=O)=CC=C2C

For research use only. We do not sell to patients.

Summary

AWL-II-38.3 is a potent ephrin-A receptor (EphA3) kinase inhibitor. AWL-II-38.3 does not exhibit significant cellular activity against Src-family kinases nor against b-raf ^[1] ^[2] ^[1] ^[2] .

IC50 & Target

Ephrin-A receptor (EphA3) kinase ^[1] ^[2]

In Vitro

AWL-II-38.3 fits to LIMK2 and LIMK1 ATP-binding and substrate-binding pockets ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 66.67 mg/mL ( 142.03 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1303 mL	10.6514 mL	21.3029 mL
5 mM	0.4261 mL	2.1303 mL	4.2606 mL
10 mM	0.2130 mL	1.0651 mL	2.1303 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (5.33 mM); Clear solution

* All of the co-solvents are available by MCE.