[CAS NO. 1135219-23-6] ALW-II-49-7
PRODUCTS SPECIFICATIONS [1135219-23-6]
DESCRIPTION [1135219-23-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 414.38 |
| Molecular Formula | C21H17F3N4O2 |
| SMILES | O=C(C1=CC(NC2=CC(C(NC3=CC=CC(C(F)(F)F)=C3)=O)=CC=C2C)=CN=C1)N |
Summary
IC50 & Target
EphB2 [1]
In Vitro
ALW-II-49-7 (compound 9) exhibits selectivity profile of binding to a set of kinases including b-raf, CSF1R, DDR1, DDR2, EphA2, EphA5, EphA8, EphB1, EphB2, EphB3, Frk, Kit, Lck, p38a, p38b, PDGFRa, PDGFRb, and Raf1
[1]
.
ALW-II-49-7 (0.01-10 μM; 1 h) inhibits EphB2 tyrosine kinase activity in U87 glioblastoma cells. EphB2 is added in media at 2 μg/mL
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.