[CAS NO. 113942-30-6] Temozolomide acid

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PRODUCTS SPECIFICATIONS [113942-30-6]

Catalog

HY-W018326

Brand

MCE

CAS

113942-30-6

DESCRIPTION [113942-30-6]

Overview

MDL	MFCD12032160
Molecular Weight	195.14
Molecular Formula	C6H5N5O3
SMILES	CN1N=NC2=C(N=CN2C1=O)C(O)=O

For research use only. We do not sell to patients.

Summary

Temozolomide acid is a carboxylic acid derivative of Temozolomide. Temozolomide is a DNA alkylating agent, methylating the guanine and adenine bases of DNA, causing breaks in DNA double strand, cell cycle arrest, and eventually cell death. Temozolomide acid has an activity similar to the parent compound Temozolomide with the same anticancer activity ^[1] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 512.45 mM ; Need ultrasonic)

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Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.1245 mL	25.6226 mL	51.2453 mL
5 mM	1.0249 mL	5.1245 mL	10.2491 mL
10 mM	0.5125 mL	2.5623 mL	5.1245 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (12.81 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (12.81 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (12.81 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Helal DO, et al. A natural protein based platform for the delivery of Temozolomide acid to glioma cells. Eur J Pharm Biopharm. 2021 Dec;169:297-308.