[CAS NO. 114482-86-9] Oroxin B
PRODUCTS SPECIFICATIONS [114482-86-9]
DESCRIPTION [114482-86-9]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 594.52 |
| Molecular Formula | C27H30O15 |
| SMILES | O=C1C=C(C2=CC=CC=C2)OC3=CC(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO[C@H]5[C@@H]([C@H]([C@@H]([C@@H](CO)O5)O)O)O)O4)O)O)O)=C(O)C(O)=C13 |
2 Publications Citing Use of MCE
Summary
Oroxin B (OB) is a flavonoid isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent. Oroxin B (OB) possesses obvious inhibitory effect and induces early apoptosis rather than late apoptosis on liver cancer cells through upregulation of PTEN , down regulation of COX-2 , VEGF , PI3K , and p-AKT [1] . Oroxin B (OB) selectively induces tumor-suppressive ER stress in malignant lymphoma cells [2] .
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL ( 168.20 mM ; Need ultrasonic)
H 2 O : < 0.1 mg/mL (ultrasonic) (insoluble)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.6820 mL | 8.4101 mL | 16.8203 mL |
| 5 mM | 0.3364 mL | 1.6820 mL | 3.3641 mL |
| 10 mM | 0.1682 mL | 0.8410 mL | 1.6820 mL |
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Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (4.21 mM); Clear solution
References
- [1] Li NN, et al. Evidence for the Involvement of COX-2/VEGF and PTEN/Pl3K/AKT Pathway the Mechanism of Oroxin B Treated Liver Cancer. Pharmacogn Mag. 2018 Apr-Jun;14(54):207-213.
- [2] Yang P, et al. Oroxin B selectively induces tumor-suppressive ER stress and concurrently inhibits tumor-adaptive ER stress in B-lymphoma cells for effective anti-lymphoma therapy. Toxicol Appl Pharmacol. 2015 Oct 15;288(2):269-79.
Synonyms