[CAS NO. 1149-99-1] IlludinS

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PRODUCTS SPECIFICATIONS [1149-99-1]

Catalog

HY-125098

Brand

MCE

CAS

1149-99-1

DESCRIPTION [1149-99-1]

Overview

MDL	-
Molecular Weight	264.32
Molecular Formula	C15H20O4
SMILES	O=C1C2=C[C@](C)([C@@H](C2=C(C3([C@@]1(C)O)CC3)C)O)CO

For research use only. We do not sell to patients.

Summary

Illudin S, a cytotoxic Illudin, is a natural sesquiterpene with strong anti-tumour and antiviral activities. Illudin S has genotoxic activities. Illudin S blocks the G1-S phase interface of the cell cycle in human leukemia cells ^[1] ^[2] ^[3] ^[4] .

In Vitro

Illudin S (0-0.26 nM; 24-72 hours) shows cytotoxicity in human fibroblasts ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay ^[2]

Cell Line:	Human fibroblasts
Concentration:	0-0.26 nM
Incubation Time:	24 hours, 72 hours
Result:	Decreased cell survival.

Appearance

Solid

Source

Lampteromyces japonicus

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 189.16 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7833 mL	18.9165 mL	37.8329 mL
5 mM	0.7567 mL	3.7833 mL	7.5666 mL
10 mM	0.3783 mL	1.8916 mL	3.7833 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (9.46 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (9.46 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

Spiro[cyclopropane-1,5′-[5H]inden]-7′(6′H)-one, 2′,3′-dihydro-3′,6′-dihydroxy-2′-(hydroxymethyl)-2′,4′,6′-trimethyl-, (2′S,3′R,6′R)-

Illudin S

Spiro[cyclopropane-1,5′-[5H]inden]-7′(6′H)-one, 2′,3′-dihydro-3′,6′-dihydroxy-2′-(hydroxymethyl)-2′,4′,6′-trimethyl-, [2′S-(2′α,3′β,6′α)]-

(2′S,3′R,6′R)-2′,3′-Dihydro-3′,6′-dihydroxy-2′-(hydroxymethyl)-2′,4′,6′-trimethylspiro[cyclopropane-1,5′-[5H]inden]-7′(6′H)-one

Illudine S

Lampterol

Lunamycin

NSC 400979

NSC 626369