[CAS NO. 116313-94-1] Nitecapone

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PRODUCTS SPECIFICATIONS [116313-94-1]

Catalog

HY-106842

Brand

MCE

CAS

116313-94-1

DESCRIPTION [116313-94-1]

Overview

MDL	MFCD00866318
Molecular Weight	265.22
Molecular Formula	C12H11NO6
SMILES	CC(/C(C(C)=O)=C/C1=CC([N+]([O-])=O)=C(O)C(O)=C1)=O

For research use only. We do not sell to patients.

Summary

Nitecapone (OR-462) is an orally active and short-acting catechol-O-methyltransferase (COMT) inhibitor with gastroprotective and antioxidant properties. Nitecapone (OR-462) scavenges reactive oxygen and nitric radicals and prevents lipid peroxidation ^[1] ^[2] ^[3] .

In Vitro

Nitecapone (1-100 μM) reducesd GSH (reduced glutathione) depletion induced by ROO ^- by 11-38% and oxidation to oxidized glutathione (GSSG) by 32-45% ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Nitecapone (30 mg/kg, ip daily for 13 days) reduces development and symptoms of neuropathic pain after spinal nerve ligation in rats ^[3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Eighty-six male Wistar rats, weighing 140-350 g ^[3] .
Dosage:	30 mg/kg (3.3 mL/kg).
Administration:	IP, once daily for 13 days.
Result:	Selectively and specifically inhibits COMT in the peripheral tissues, and to some extent in the CNS for ca. 3 h. Increased the thresholds for the mechanical stimuli and thus reduced mechanical allodynia. Reduced the number of positive reactions of the ipsilateral paws when compared with the baselines in the nitecapone-pretreated rats.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 188.52 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7705 mL	18.8523 mL	37.7045 mL
5 mM	0.7541 mL	3.7705 mL	7.5409 mL
10 mM	0.3770 mL	1.8852 mL	3.7705 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (7.84 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

2,4-Pentanedione, 3-[(3,4-dihydroxy-5-nitrophenyl)methylene]-

3-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-2,4-pentanedione

OR 462

Nitecapone

3-[(3,4-Dihydroxy-5-nitrophenyl)methylidene]pentane-2,4-dione