[CAS NO. 117977-21-6] Rabeprazole Sulfide

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PRODUCTS SPECIFICATIONS [117977-21-6]

Catalog

HY-W003467

Brand

MCE

CAS

117977-21-6

DESCRIPTION [117977-21-6]

Overview

MDL	MFCD08063845
Molecular Weight	343.44
Molecular Formula	C18H21N3O2S
SMILES	CC1=C(OCCCOC)C=CN=C1CSC2=NC3=CC=CC=C3N2

For research use only. We do not sell to patients.

Summary

Rabeprazole Sulfide is an active metabolite of Rabeprazole. Rabeprazole is a proton pump inhibitor that suppresses gastric acid secretion through an interaction with (H ⁺ /K ⁺ )-ATPase in gastric parietal cells. Rabeprazole markedly inhibits the motility of H. pylori . Rabeprazole has the potential for various peptic diseases treatment ^[1] ^[2] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 291.17 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9117 mL	14.5586 mL	29.1172 mL
5 mM	0.5823 mL	2.9117 mL	5.8234 mL
10 mM	0.2912 mL	1.4559 mL	2.9117 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (7.28 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (7.28 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (7.28 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

1H-Benzimidazole, 2-[[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl]thio]-

2-[[[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl]thio]-1H-benzimidazole

H 295/43

2-[[[3-Methyl-4-(3-methoxypropoxy)-2-pyridyl]methyl]thio]-1H-benzimidazole

Rabeprazole-thioether

2-[((4-(3-Methoxypropoxy)-3-methylpyridine-2-yl)methyl)thio]-1H-benzimidazole

2-(((4-(3-Methoxypropoxy)-3-methylpyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole

2-[[4-(3-Methoxypropoxy)-3-methylpyridin-2-yl]methylsulfanyl]-1H-benzimidazole