[CAS NO. 118-00-3]  Guanosine

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PRODUCTS SPECIFICATIONS [118-00-3]

Catalog
HY-N0097
Brand
MCE
CAS
118-00-3

DESCRIPTION [118-00-3]

Overview

MDLMFCD00010182
Molecular Weight283.24
Molecular FormulaC10H13N5O5
SMILESOC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(N=C(N)NC3=O)=C3N=C2)O1

For research use only. We do not sell to patients.


Summary

Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti- HSV activity.


IC50 & Target

Human Endogenous Metabolite


In Vitro

Guanosine can be phosphorylated to become guanosine monophosphate (GMP), cyclic guanosine monophosphate (cGMP), guanosine diphosphate (GDP), and guanosine triphosphate (GTP). These forms play important roles in various biochemical processes such as synthesis of nucleic acids and proteins, photosynthesis, muscle contraction, and intracellular signal transduction (cGMP).

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)


Solvent & Solubility

In Vitro:

DMSO : ≥ 75 mg/mL ( 264.79 mM )

H 2 O : 1 mg/mL ( 3.53 mM ; Need ultrasonic)

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5306 mL 17.6529 mL 35.3057 mL
5 mM 0.7061 mL 3.5306 mL 7.0612 mL
10 mM 0.3531 mL 1.7653 mL 3.5306 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

    Solubility: 3.33 mg/mL (11.76 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: ≥ 2.5 mg/mL (8.83 mM); Clear solution

  • 3.

    Add each solvent one by one: 10% DMSO >> 90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.83 mM); Clear solution

* All of the co-solvents are available by MCE.


Synonyms

Guanosine
Guanine, 9-β-D-ribofuranosyl-
Inosine, 2-amino-
Vernine
β-D-Ribofuranoside, guanine-9
6H-Purin-6-one, 2-amino-1,9-dihydro-9-β-D-ribofuranosyl-
2-Amino-1,9-dihydro-9-β-D-ribofuranosyl-6H-purin-6-one
Guanine ribonucleoside
NSC 19994
DL-Guanosine
7: PN: WO2013104540 PAGE: 124 claimed sequence