[CAS NO. 1186372-20-2] TMN355
PRODUCTS SPECIFICATIONS [1186372-20-2]
DESCRIPTION [1186372-20-2]
Overview
| MDL | MFCD19440965 |
|---|---|
| Molecular Weight | 380.80 |
| Molecular Formula | C21H14ClFN2O2 |
| SMILES | O=C(NC(NC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)C4=C(F)C=CC=C4Cl |
1 Publications Citing Use of MCE
Summary
TMN355 is a potent chemical cyclophilin A inhibitor and reduces foam cell formation and cytokine secretion. TMN355 is used for atherosclerosis [1] .
IC50 & Target
cyclophilin A [1]
In Vitro
TMN 355 (0.5-10 μM; 3-9 hours) results in 75.9% reduction of cyclophilin A protein expression. And 1 μM TMN 355 inhibits cyclophilin A after 6 h of activation [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Western Blot Analysis [1]
| Cell Line: | THP cell lines |
| Concentration: | 0.5, 1, 2.5, 5 and 10 μM |
| Incubation Time: | 3, 6 and 9 hours |
| Result: | Resulted in 75.9% reduction of cyclophilin A protein expression. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 31.25 mg/mL ( 82.06 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.6261 mL | 13.1303 mL | 26.2605 mL |
| 5 mM | 0.5252 mL | 2.6261 mL | 5.2521 mL |
| 10 mM | 0.2626 mL | 1.3130 mL | 2.6261 mL |
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1.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.08 mg/mL (5.46 mM); Clear solution