[CAS NO. 1186649-91-1] ML-109
PRODUCTS SPECIFICATIONS [1186649-91-1]
DESCRIPTION [1186649-91-1]
Overview
| MDL | MFCD31746908 |
|---|---|
| Molecular Weight | 523.58 |
| Molecular Formula | C31H29N3O5 |
| SMILES | CC(NC1=CC=C(OCC2=CC(C(N3CC4=CC=CC=C4)NC5=C(C(O)=CC=C5)C3=O)=CC=C2OC)C=C1)=O |
Summary
ML-109 is a potent and full thyroid stimulating hormone receptor (TSHR) agonist, with an EC 50 of 40 nM.
IC50 & Target
EC50: 40 nM (TSHR) [1] .
In Vitro
ML-109 (Compound 2) is a full agonist at TSHR with an EC 50 of 40 nM and, like compound 1, it has no activity at FSHR or LHCGR. ML-109 contains an aminal, a functional group that is subject to hydrolysis and/or other degradation mechanisms. ML-109 is surprisingly stable at neutral and basic conditions (t 1/2 of ~16 h) but is found to degrade at low pH (t 1/2 of ~3 h) [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 83.33 mg/mL ( 159.15 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.9099 mL | 9.5496 mL | 19.0993 mL |
| 5 mM | 0.3820 mL | 1.9099 mL | 3.8199 mL |
| 10 mM | 0.1910 mL | 0.9550 mL | 1.9099 mL |