[CAS NO. 119-84-6] Dihydrocoumarin
PRODUCTS SPECIFICATIONS [119-84-6]
DESCRIPTION [119-84-6]
Overview
| MDL | MFCD00006881 |
|---|---|
| Molecular Weight | 148.16 |
| Molecular Formula | C9H8O2 |
| SMILES | O=C1CCC2=CC=CC=C2O1 |
Summary
IC50 & Target
|
hSIRT1 208 μM (IC 50 ) |
hSIRT2 295 μM (IC 50 ) |
In Vitro
Dihydrocoumarin induces a concentration-dependent inhibition of SIRT1 (IC
50
of 208 μM) in an in vitro enzymatic assay. A decrease in SIRT1 deacetylase activity is observed even at micromolar doses (85±5.8 and 73±13.7% activity at 1.6 μM and 8 μM, respectively). The microtubule SIRT2 deacetylase is also inhibited with a similar dose dependency (IC
50
of 295 μM)
[1]
.
Dihydrocoumarin (1-5 mM) increases cytotoxicity in the TK6 cell line in a dose-dependent manner following a 24-h exposure. Dihydrocoumarin (1-5 mM) increases apoptosis in a dose-dependent manner in the TK6 cell line at the 6-h time point. A 5-mM dose of Dihydrocoumarin increases apoptosis at the 6-h time point in the TK6 cell line
[1]
.
Dihydrocoumarin (1-5 mM) increases p53 lysine 373 and 382 acetylation in a dose-dependent manner in the TK6 cell line following a 24-h exposure period
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
<24°C Solid,>25°C Liquid
Source
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Pure form | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 674.95 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 6.7495 mL | 33.7473 mL | 67.4946 mL |
| 5 mM | 1.3499 mL | 6.7495 mL | 13.4989 mL |
| 10 mM | 0.6749 mL | 3.3747 mL | 6.7495 mL |
Synonyms