[CAS NO. 1197896-79-9] NITD-2

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PRODUCTS SPECIFICATIONS [1197896-79-9]

Catalog

HY-134665

Brand

MCE

CAS

1197896-79-9

DESCRIPTION [1197896-79-9]

Overview

MDL	-
Molecular Weight	433.48
Molecular Formula	C23H19N3O4S
SMILES	O=C(O)C1=CC=CC=C1NS(=O)(C2=CC=CC(C3=CN(CC4=CC=CC=C4)N=C3)=C2)=O

For research use only. We do not sell to patients.

Summary

NITD-2, a dengue virus (DENV) polymerase inhibitor, inhibits the DENV RdRp-mediated RNA elongation. NITD-2 penetrates cell membrane poorly ^[1] .

In Vitro

NITD-2 inhibits de novo RNA synthesis ^[1] .
NITD-2 exhibited no antiviral activity in cell culture resulted from the poor cell penetratration ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 230.69 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3069 mL	11.5346 mL	23.0691 mL
5 mM	0.4614 mL	2.3069 mL	4.6138 mL
10 mM	0.2307 mL	1.1535 mL	2.3069 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (5.77 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Pornwaratt Niyomrattanakit, et al. Inhibition of dengue virus polymerase by blocking of the RNA tunnel. J Virol. 2010 Jun;84(11):5678-86.