[CAS NO. 1198786-98-9] INT-777 (R-enantiomer)

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PRODUCTS SPECIFICATIONS [1198786-98-9]

Catalog

HY-15677A

Brand

MCE

CAS

1198786-98-9

MDL	-
Molecular Weight	450.65
Molecular Formula	C27H46O5
SMILES	O[C@@H]1CC[C@@]2(C)[C@@]([C@@H](CC)[C@@H](O)[C@]3([H])[C@]2([H])C[C@H](O)[C@@]4(C)[C@@]3([H])CC[C@@H]4[C@H](C)C[C@@H](C)C(O)=O)([H])C1

For research use only. We do not sell to patients.

INT-777 (R-enantiomer) is the R-enantiomer of INT-777, with EC ₅₀ of 4.79 μM for TGR5, and less potent than INT-777.

INT-777 (R-enantiomer) is more choleretic than CA (4), but less than INT-777 ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Solid

Room temperature in continental US; may vary elsewhere.

In Vitro:

DMSO : ≥ 100 mg/mL ( 221.90 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (5.55 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (5.55 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (5.55 mM); Clear solution

* All of the co-solvents are available by MCE.