[CAS NO. 120-46-7] Dibenzoylmethane
PRODUCTS SPECIFICATIONS [120-46-7]
DESCRIPTION [120-46-7]
Overview
| MDL | MFCD00003085 |
|---|---|
| Molecular Weight | 224.26 |
| Molecular Formula | C15H12O2 |
| SMILES | O=C(C1=CC=CC=C1)CC(C2=CC=CC=C2)=O |
Summary
Dibenzoylmethane, a minor ingredient in licorice, activates Nrf2 and prevents various cancers and oxidative damage. Dibenzoylmethane, an analog of curcumin, results in dissociation from Keap1 and nuclear translocation of Nrf2 [1] .
In Vitro
Dibenzoylmethane (10, 20, 30, 40, 50 μM; 6 hours) treatment concentration-dependently increases the mRNA level of HO-1 but has no effect on the mRNA level of Nrf2 in HepG2 cells. Dibenzoylmethane induces HO-1 and Nrf2 protein expression, and the induction diminishes after 12 h
[1]
.
Dibenzoylmethane (10, 20, 30, 40, 50 μM; 2 hours) concentration-dependently increases the phosphorylated protein levels of Erk1/2, p38MAPK, JNK, AMPK, and Akt in HepG2 cells.
Dibenzoylmethane does not show significant cytotoxicity
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Dibenzoylmethane (200, 500 mg/kg/day; ip; for three consecutive days) pretreatment significantly reduces both the area and the severity of necrosis, as well as the leukocyte infiltration, at a dose of 200 mg/kg in wild-type and Nrf2 knockout mice
[1]
.
Dibenzoylmethane protectes against CCl4-induced (1:49,v/v, 10 ml/kg) liver damage in wild-type mice
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 445.91 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 4.4591 mL | 22.2956 mL | 44.5911 mL |
| 5 mM | 0.8918 mL | 4.4591 mL | 8.9182 mL |
| 10 mM | 0.4459 mL | 2.2296 mL | 4.4591 mL |
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1.
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Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (11.15 mM); Clear solution
Synonyms