[CAS NO. 1204329-34-9] BI-9627
PRODUCTS SPECIFICATIONS [1204329-34-9]
DESCRIPTION [1204329-34-9]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 356.34 |
| Molecular Formula | C16H19F3N4O2 |
| SMILES | NC(NC(C1=CC=C(C2CCN(C(C)=O)CC2)C(C(F)(F)F)=C1)=O)=N |
Summary
BI-9627 is potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor, with IC 50 s of 6 and 31 nM in intracellular pH recovery (pHi) and human platelet swelling assays, respectively. BI-9627 displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 shows low DDI (drug-drug interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury [1] .
IC50 & Target
IC50: 6 nM (NHE1 in intracellular pH recovery assay), 31 nM (NHE1 in human platelet swelling assay) [1]
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 280.63 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.8063 mL | 14.0315 mL | 28.0631 mL |
| 5 mM | 0.5613 mL | 2.8063 mL | 5.6126 mL |
| 10 mM | 0.2806 mL | 1.4032 mL | 2.8063 mL |