[CAS NO. 120447-62-3] (±)-Vesamicol hydrochloride

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PRODUCTS SPECIFICATIONS [120447-62-3]

Catalog

HY-B1813A

Brand

MCE

CAS

120447-62-3

DESCRIPTION [120447-62-3]

Overview

MDL	-
Molecular Weight	295.85
Molecular Formula	C17H26ClNO
SMILES	O[C@H]1[C@H](N2CCC(C3=CC=CC=C3)CC2)CCCC1.[H]Cl

For research use only. We do not sell to patients.

Summary

(±)-Vesamicol hydrochloride ((±)-AH5183 hydrochloride) is a potent vesicular acetylcholine transport inhibitor with a K _i of 2 nM. (±)-Vesamicol hydrochloride also displays high affinity for σ1 and σ2 receptors with K _i s of 26 nM and 34 nM, respectively ^[1] ^[2] .

IC50 & Target

Ki: 2 nM (Vesicular acetylcholine transport), 26 nM (σ1 receptors) and 34 nM (σ2 receptors) ^[1]

In Vitro

The pharmacological actions of (±)-Vesamicol have been attributed to inhibition of acetylcholine transport into synaptic vesicles and the subsequent quantal release of acetylcholine ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

(±)-Vesamicol (3 mg/kg; intraperitoneal injection; once; male Wistar rats) treatment increases the levels of cytosolic acetylcholine (ACh) in all regions of the brain, while those of vesicular ACh decreased in all regions except for the striatum ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats (120-300 g) ^[2]
Dosage:	3 mg/kg
Administration:	Intraperitoneal injection; once
Result:	The levels of cytosolic acetylcholine (ACh) increased in all regions of the brain, while those of vesicular ACh decreased in all regions except for the striatum.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 20.83 mg/mL ( 70.41 mM ; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3801 mL	16.9005 mL	33.8009 mL
5 mM	0.6760 mL	3.3801 mL	6.7602 mL
10 mM	0.3380 mL	1.6900 mL	3.3801 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (7.03 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (7.03 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (7.03 mM); Clear solution

* All of the co-solvents are available by MCE.