[CAS NO. 1208315-24-5] N6022

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [1208315-24-5]

Catalog

HY-14984

Brand

MCE

CAS

1208315-24-5

DESCRIPTION [1208315-24-5]

Overview

MDL	MFCD22123247
Molecular Weight	414.46
Molecular Formula	C24H22N4O3
SMILES	OC(CCC1=CC=C(N1C2=CC=C(C(N)=O)C=C2C)C(C=C3)=CC=C3N4C=CN=C4)=O

For research use only. We do not sell to patients.

9 Publications Citing Use of MCE

Summary

N6022 is a potent, selective, reversible, and efficacious S-Nitrosoglutathione reductase(GSNOR) inhibitor with IC ₅₀ of 8 nM.

IC50 & Target

IC50: 8 nM (GSNOR) ^[2]

In Vitro

N6022 shows concentration-dependent binding to rat plasma proteins. N6022 has more effect on ATP at lower drug concentrations (20 μM) than on GSH ^[1] . N6022 binds in the GSNO substrate binding pocket like a competitive inhibitor with an IC ₅₀ of 8 nM and a K _i of 2.5 nM. N6022 is uncompetitive with cofactors NAD ⁺ and NADH ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

N6022 (50 mg/kg)-treated rats show a slight increase in the incidence of granulomas. In serum, N6022 remains in solution up to 5 mg/mL ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT01746784	Nivalis Therapeutics, Inc.	Cystic Fibrosis	February 2014	Phase 1
NCT01147406	Nivalis Therapeutics, Inc.	Healthy	August 2010	Phase 1

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 46 mg/mL ( 110.99 mM )

H ₂ O : < 0.1 mg/mL (insoluble)

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4128 mL	12.0639 mL	24.1278 mL
5 mM	0.4826 mL	2.4128 mL	4.8256 mL
10 mM	0.2413 mL	1.2064 mL	2.4128 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (6.03 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (6.03 mM); Clear solution

* All of the co-solvents are available by MCE.