[CAS NO. 120964-45-6] 3-Deazaneplanocin A hydrochloride

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PRODUCTS SPECIFICATIONS [120964-45-6]

Catalog

HY-12186G

Brand

MCE

CAS

120964-45-6

DESCRIPTION [120964-45-6]

Overview

MDL	MFCD18782644
Molecular Weight	298.73
Molecular Formula	C12H15ClN4O3
SMILES	O[C@@H]1[C@H](O)C(CO)=C[C@H]1N2C=NC3=C2C=CN=C3N.[H]Cl

For research use only. We do not sell to patients.

6 Publications Citing Use of MCE

Summary

3-Deazaneplanocin A (DZNep) hydrochloride (GMP) is 3-Deazaneplanocin A hydrochloride (HY-12186) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. 3-Deazaneplanocin A hydrochloride is a potent histone methyltransferase EZH2 inhibitor ^[1] ^[2] .

IC50 & Target

EZH2

In Vitro

3-Deazaneplanocin A (20-200 nM, during 16-28 day) stimulates Oct4 expression in chemically induced pluripotent stem cells (CiPSCs) ^[2] .
3-Deazaneplanocin A (20-200 nM, during 16-28 day) inhibits DNA and H3K9 methylation at the Oct4 promoter in CiPSCs ^[2] .
3-Deazaneplanocin A (10 nM, 24 h) promotes developmental competence of cloned pig embryos ^[3] .
3-Deazaneplanocin A (10 nM, 24 h) decreases the levels of H3K27me3 and H3K9me2 at the 2-cell, 4-cell and blastocyst stages ^[3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence ^[3]

Cell Line:	Cloned pig embryos
Concentration:	10 nM
Incubation Time:	24 h
Result:	Decreased H3K27me3 and H3K9me2 by approximately 45%, 37% and 7% at the 2-cell, 4-cell and blastocyst stages, respectively.

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Please store the product under the recommended conditions in the Certificate of Analysis.