[CAS NO. 124265-89-0] Omaciclovir
PRODUCTS SPECIFICATIONS [124265-89-0]
DESCRIPTION [124265-89-0]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 253.26 |
| Molecular Formula | C10H15N5O3 |
| SMILES | O=C1NC(N)=NC2=C1N=CN2C[C@H](CO)CCO |
Summary
Omaciclovir (H2G) is a potent and selective inhibitor of herpesvirus replication. Omaciclovir is a nucleoside analog with antiviral activity [1] .
In Vitro
Omaciclovir is a nucleoside analog with in vitro inhibitory activity against varicella-zoster virus (VZV), herpes simplex virus types 1 and 2 (HSV-1 and -2), Epstein-Barr virus, and human herpesvirus 6. Omaciclovir is also efficacious in simian varicella virus-infected monkeys
[1]
.
Omaciclovir shows antiviral activities against different human herpesviruses with EC
50
s of 0.72 ± 0.1, 0.62 ± 0.2, 0.015 ± 0.004, 0.048 ± 0.023, 0.047 ± 0.004, 0.035 ± 0.022, and 0.016 ± 0.003 μM for MRC-5 VZV-32, MRC-5 Molly, MeWo VZV-32, MeWo Molly, MeWo Emily, MeWo VZ11, and MeWo VZ30, respectively
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 230 mg/mL ( 908.16 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.9485 mL | 19.7426 mL | 39.4851 mL |
| 5 mM | 0.7897 mL | 3.9485 mL | 7.8970 mL |
| 10 mM | 0.3949 mL | 1.9743 mL | 3.9485 mL |