[CAS NO. 1252362-53-0] LRE1
PRODUCTS SPECIFICATIONS [1252362-53-0]
DESCRIPTION [1252362-53-0]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 280.78 |
| Molecular Formula | C12H13ClN4S |
| SMILES | NC1=NC(N(CC2=CC=CS2)C3CC3)=CC(Cl)=N1 |
1 Publications Citing Use of MCE
Summary
LRE1 is a specific and allosteric inhibitor of soluble adenylyl cyclase .
IC50 & Target
Adenylyl cyclase [1]
In Vitro
LRE1 binds to the bicarbonate activator binding site and inhibits soluble adenylyl cyclase (sAC) via a unique allosteric mechanism [1] .
LRE1 prevents sAC-dependent processes in cellular and physiological systems and facilitates exploration of the therapeutic potential of sAC inhibition [1] .
LRE1 (0.5-100 μM, 60 minutes ) inhibits sperm and mitochondrial functions of sAC [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Western Blot Analysis [1]
| Cell Line: | Mouse cauda sperm |
| Concentration: | 0.5-100 µM |
| Incubation Time: | 60 minutes |
| Result: | LRE1 inhibits sAC dependent sperm capacitation [1] . |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 125 mg/mL ( 445.19 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.5615 mL | 17.8075 mL | 35.6151 mL |
| 5 mM | 0.7123 mL | 3.5615 mL | 7.1230 mL |
| 10 mM | 0.3562 mL | 1.7808 mL | 3.5615 mL |