[CAS NO. 1253452-78-6] KS176
PRODUCTS SPECIFICATIONS [1253452-78-6]
DESCRIPTION [1253452-78-6]
Overview
| MDL | MFCD22666402 |
|---|---|
| Molecular Weight | 405.40 |
| Molecular Formula | C22H19N3O5 |
| SMILES | O=C(C1=C(NC(C2=CC=C([N+]([O-])=O)C=C2)=O)C=CC=C1)NC3=CC=C(CCO)C=C3 |
1 Publications Citing Use of MCE
Summary
KS176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter (IC50 values are 0.59 and 1.39 μM in Pheo A and Hoechst 33342 assays respectively). Displays no inhibitory activity against P-gp or MRP1. IC50 value: 0.59( in Pheo A assay), 1.39 μM (in Hoechst 33342 assay). Target: BCRP The more detailed information please refer to Compound 9 in the reference.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 35 mg/mL ( 86.33 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.4667 mL | 12.3335 mL | 24.6670 mL |
| 5 mM | 0.4933 mL | 2.4667 mL | 4.9334 mL |
| 10 mM | 0.2467 mL | 1.2333 mL | 2.4667 mL |