[CAS NO. 126-17-0] Solasodine

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PRODUCTS SPECIFICATIONS [126-17-0]

Catalog

HY-N0068

Brand

MCE

CAS

126-17-0

DESCRIPTION [126-17-0]

Overview

MDL	MFCD00037844
Molecular Weight	413.64
Molecular Formula	C27H43NO2
SMILES	C[C@H](CC1)CN[C@]21O[C@@]3([H])C[C@@]4([H])[C@]5([H])CC=C6C[C@@H](O)CC[C@]6(C)[C@@]5([H])CC[C@]4(C)[C@@]3([H])[C@@H]2C

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]Drug Res. 2022 Jun 20.

Summary

Solasodine (Purapuridine) is a steroidal alkaloid that occurs in plants of the Solanaceae family. Solasodine has neuroprotective, antifungal, hypotensive, anticancer, antiatherosclerotic, antiandrogenic and anti-inflammatory activities ^[1] ^[2] .

In Vitro

Solasodine (90 μM; 2 days) treatment displays significant sprouting in P19 cells. Solasodine induces strong expression of the different neuronal markers studied, including βIII-tubulin, synaptophysin, MAP2, ChAT, and neuroblast marker doublecortin. Solasodine induces the differentiation of P19 cells, essentially towards the neuronal pathway ^[1] . Solasodine induce apoptosis by inhibiting the p53-MDM2 complex, p21 ^Waf1/Cip1 , and Bcl-2 proteins ^[3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Solasodine (25-100 mg/kg; intraperitoneal injection; once) treatment significantly delays latency of hind limb tonic extensor (HLTE) phase in the PCT-induced convulsions. And significantly potentiates Thiopental-provoked sleep in a dose-dependent manner. Solasodine has anticonvulsant and CNS depressant activities ^[2] .
Solasodine (375 μM; i.c.v.; for 2 weeks) treatment results a significant increase in bromodeoxyuridine uptake by cells of the ependymal layer, subventricular zone, and cortex that co-localized with doublecortin immunostaining. Solasodine treatment in rats results in a dramatic increase in expression of the cholesterol- and drug-binding translocator protein in ependymal cells ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Swiss albino mice (18-25 g) treated with Picrotoxin (PCT) or Thiopental ^[2]
Dosage:	25 mg/kg, 50 mg/kg and 100 mg/kg
Administration:	Intraperitoneal injection; once
Result:	Significantly delayed latency of hind limb tonic extensor (HLTE) phase in the PCT-induced convulsions. And significantly potentiated Thiopental-provoked sleep in a dose-dependent manner.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT04693000	Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh	Keratotic Nodular Size	September 23, 2018	Phase 2

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 2.6 mg/mL ( 6.29 mM ; Need ultrasonic)

H ₂ O : 0.67 mg/mL ( 1.62 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4176 mL	12.0878 mL	24.1756 mL
5 mM	0.4835 mL	2.4176 mL	4.8351 mL
10 mM	---	---	---

* Please refer to the solubility information to select the appropriate solvent.

References

Synonyms

Spirosol-5-en-3-ol, (3β,22α,25R)-

Solasod-5-en-3β-ol

Spiro[8H-naphth[2′,1′:4,5]indeno[2,1-b]furan-8,2′-piperidine], spirosol-5-en-3-ol deriv.

(3β,22α,25R)-Spirosol-5-en-3-ol

Purapuridine

Solancarpidine

Solasodin

Solasodine

NSC 178260

NSC 179187

(-)-Solasodine