[CAS NO. 1264754-13-3] PROTAC ERRα ligand 1

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PRODUCTS SPECIFICATIONS [1264754-13-3]

Catalog

HY-U00425

Brand

MCE

CAS

1264754-13-3

DESCRIPTION [1264754-13-3]

Overview

MDL	MFCD30741543
Molecular Weight	420.36
Molecular Formula	C19H11F3N2O4S
SMILES	N#CC1=CC=C(OC2=CC=C(/C=C(SC(N3)=O)/C3=O)C=C2OC)C(C(F)(F)F)=C1

For research use only. We do not sell to patients.

Summary

PROTAC ERRα ligand 1 is an estrogen-related receptor α ( ERRα ) antagonist with IC ₅₀ s of 0.04 and 2.8 μM for ERRα and ERRγ , respectively ^[1] .

IC50 & Target

ERRα

0.04 μM (IC ₅₀ )

ERRγ

2.8 μM (IC ₅₀ )

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 237.89 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3789 mL	11.8946 mL	23.7891 mL
5 mM	0.4758 mL	2.3789 mL	4.7578 mL
10 mM	0.2379 mL	1.1895 mL	2.3789 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (5.95 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Patch RJ, et al. Identification of diaryl ether-based ligands for estrogen-related receptor α as potential antidiabetic agents. J Med Chem. 2011 Feb 10;54(3):788-808.