[CAS NO. 1285702-20-6] ML167
PRODUCTS SPECIFICATIONS [1285702-20-6]
DESCRIPTION [1285702-20-6]
Overview
| MDL | MFCD27978379 |
|---|---|
| Molecular Weight | 335.36 |
| Molecular Formula | C19H17N3O3 |
| SMILES | OCC1=CC=C(C2=CC3=C(NCC4=CC=C(C)O4)N=CN=C3C=C2)O1 |
Summary
ML167 is a highly selective Cdc2-like kinase 4 ( Clk4 ) inhibitor with IC 50 of 136 nM, >10-fold selectivity for closely related kinases Clk1, Clk2, Clk3 and Dyrk1A/1B [1] .
IC50 & Target
|
CLK4 136 nM (IC 50 ) |
CLK1 1522 nM (IC 50 ) |
CLK2 1648 nM (IC 50 ) |
DYRK1B 4420 nM (IC 50 ) |
CDK3 ＞10000 nM (IC 50 ) |
DYRK1A ＞10000 nM (IC 50 ) |
In Vitro
ML167 has cell permeability in Caco-2 cells. ML167 contains a furan ring which liable to in vivo metabolism.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 16.67 mg/mL ( 49.71 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.9819 mL | 14.9094 mL | 29.8187 mL |
| 5 mM | 0.5964 mL | 2.9819 mL | 5.9637 mL |
| 10 mM | 0.2982 mL | 1.4909 mL | 2.9819 mL |
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1.
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2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 1.67 mg/mL (4.98 mM); Clear solution