[CAS NO. 129-16-8] Merbromin

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PRODUCTS SPECIFICATIONS [129-16-8]

Catalog

HY-B0961

Brand

MCE

CAS

129-16-8

DESCRIPTION [129-16-8]

Overview

MDL	-
Molecular Weight	752.67
Molecular Formula	C20H10Br2HgNa2O6
SMILES	O[Hg]C1=C(O[Na])C(Br)=CC(C2C3=C(C=CC=C3)C(O[Na])=O)=C1OC4=C2C=C(Br)C(O)=C4

For research use only. We do not sell to patients.

Summary

Merbromin acts as a topical antiseptic for minor cuts and scrapes and as a biological dye. Merbromin is a potent inhibitor against Zika virus (ZIKV) replication. Merbromin shows anti-ZIKV potency through ZIKVpro inhibition ^[1] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 6.67 mg/mL ( 8.86 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3286 mL	6.6430 mL	13.2860 mL
5 mM	0.2657 mL	1.3286 mL	2.6572 mL
10 mM	---	---	---

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 0.67 mg/mL (0.89 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 0.67 mg/mL (0.89 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Xiangling Cui , et al. Identification of Theaflavin-3,3'-Digallate as a Novel Zika Virus Protease Inhibitor. Front Pharmacol. 2020 Oct 21;11:514313.

Synonyms

Mercury, (2′,7′-dibromo-3′,6′-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9′-[9H]xanthen]-4′-yl)hydroxy-, sodium salt (1:2)

Mercury, [2,7-dibromo-9-(o-carboxyphenyl)-6-hydroxy-3-oxo-3H-xanthen-4-yl]hydroxy-, disodium salt

Mercury, (2′,7′-dibromo-3′,6′-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9′-[9H]xanthen]-4′-yl)hydroxy-, disodium salt

Fluorescein, 2′,7′-dibromo-4′-(hydroxymercuri)-, disodium salt

Spiro[isobenzofuran-1(3H),9′-[9H]xanthen]-3-one, 2′,7′-dibromo-3′,6′-dihydroxy-, mercury complex

Spiro[isobenzofuran-1(3H),9′-[9H]xanthene], mercury deriv.

Asceptichrome

Aseptichrome

Chromargyre

2,7-Dibromo-4-hydroxymercurifluoresceine disodium salt

Disodium 2′,7′-dibromo-4′-(hydroxymercury)fluorescein

DOMF

Flavurol

Fluorochrome

Gallochrome

Gynochrome

Merbromin

Mercuranine

Mercurochrome

Mercurocol

Mercurome

Mercurophage

No. 220 Soluble

Planochrome

Disodium 2,7-dibromo-4-(hydroxymercuri)fluorescein

Sodium 2,7-dibromo-4-hydroxymercurifluorescein

Mercurichrome

Mercuresceine

Curichrome

Curocromo

Cynochrome

Brocasept

Lapicromo

Lafircrom

Emcerol

Mercromina film

Supercromer orto

Cinfacromin

Sodium mercurescein

No. 220 sol

Mercurochrome 220 Soluble