[CAS NO. 129496-10-2] Milbemycin oxime

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PRODUCTS SPECIFICATIONS [129496-10-2]

Catalog

HY-B0778

Brand

MCE

CAS

129496-10-2

DESCRIPTION [129496-10-2]

Overview

MDL	-
Molecular Weight	1097.38
Molecular Formula	C63H88N2O14
SMILES	CC1=C[C@@H]2[C@@]3(O)[C@H](OC/C3=C\C=C\[C@H](C)C/C(C)=C/C[C@@H](O[C@@]4(CC[C@H](C)[C@@H](C)O4)C5)C[C@@H]5OC2=O)/C1=N\O.CC6=C[C@@H]7[C@@]8(O)[C@H](OC/C8=C\C=C\[C@H](C)C/C(C)=C/C[C@@H](O[C@@]9(CC[C@H](C)[C@@H](CC)O9)C%10)C[C@@H]%10OC7=O)/C6=N\O

For research use only. We do not sell to patients.

Summary

Milbemycin oxime is a macrocyclic lactone and has broad-spectrum anti- parasitic activity. Milbemycin oxime is composed of milbemycins A4 and A3. Milbemycin oxime binds glutamate-gated chloride channels. Milbemycin oxime is against intestinal nematodes, pulmonary and cardiac helminths ^[1] ^[2] ^[3] .

IC50 & Target

Macrolide

Appearance

Solid

Source

Streptomyces hygroscopicus

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL ( 91.13 mM )

H ₂ O : 1 mg/mL ( 0.91 mM ; ultrasonic and warming and heat to 80°C)

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.9113 mL	4.5563 mL	9.1126 mL
5 mM	0.1823 mL	0.9113 mL	1.8225 mL
10 mM	0.0911 mL	0.4556 mL	0.9113 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: 2.5 mg/mL (2.28 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (1.90 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (1.90 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

Milbemycin, oxime

Milbemycin oxime

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