[CAS NO. 1295541-87-5] SCD1inhibitor-4

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [1295541-87-5]

Catalog

HY-141525

Brand

MCE

CAS

1295541-87-5

DESCRIPTION [1295541-87-5]

Overview

MDL	-
Molecular Weight	363.34
Molecular Formula	C17H16F3N5O
SMILES	O=C(C1=C(C)N(CC2=CC=CC(C(F)(F)F)=C2)C=N1)NC3=NN(C)C=C3

For research use only. We do not sell to patients.

Summary

SCD1 inhibitor-4 is a potent, orally active stearoylCoA desaturase-1 ( SCD1 ) inhibitor. SCD1 inhibitor-4 can be used for the research of diabetes ^[1] .

IC50 & Target

SCD1 ^[1]

In Vivo

SCD1 inhibitor-4 (1~30 mg/kg) shows a dose-dependent decrease in desaturation index with a 55 % reduction at 1 mg/kg and 85% reduction at the 10 and 30 mg/kg doses ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 275.22 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7522 mL	13.7612 mL	27.5224 mL
5 mM	0.5504 mL	2.7522 mL	5.5045 mL
10 mM	0.2752 mL	1.3761 mL	2.7522 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (6.88 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (6.88 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (6.88 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Atkinson KA, et al. N-benzylimidazole carboxamides as potent, orally active stearoylCoA desaturase-1 inhibitors. Bioorg Med Chem Lett. 2011;21(6):1621-1625.