[CAS NO. 129655-21-6] Bizelesin
PRODUCTS SPECIFICATIONS [129655-21-6]
DESCRIPTION [129655-21-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 815.70 |
| Molecular Formula | C43H36Cl2N8O5 |
| SMILES | O=C(NC1=CC2=C(NC(C(N3C4=CC(O)=C5NC=C(C)C5=C4[C@H](CCl)C3)=O)=C2)C=C1)NC6=CC7=C(NC(C(N8C9=CC(O)=C%10NC=C(C)C%10=C9[C@H](CCl)C8)=O)=C7)C=C6 |
Summary
Bizelesin (NSC 615291; U-77779) is an AT-specific DNA alkylating agent that can generate DNA interstrand crosslinks, effectively inhibit DNA replication, and has potential anticancer activity [1] .
In Vitro
Bizelesin (0-5 μM, 4 h) can cause DNA-specific damage by targeting the AT-rich DNA domain in human cancer cell CEM cells, thereby causing damage to cancer cells, and has potential cancer therapeutic potential
[1]
.
Bizelesin (0-500 nM) causes a 50% inhibition of DNA synthesis at a concentration of 10 nM, compared to a 50% inhibition of RNA synthesis at a concentration of 160 nM, at concentrations as high as 200 nM no inhibition of protein synthesis is observed in BSC-1 cells
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
References
- [1] J M Woynarowski, et al. AT-rich islands in genomic DNA as a novel target for AT-specific DNA-reactive antitumor drugs. J Biol Chem. 2001 Nov 2;276(44):40555-66.
- [2] J M Woynarowski, et al. Effects of bizelesin (U-77,779), a bifunctional alkylating minor groove binder, on replication of genomic and simian virus 40 DNA in BSC-1 cells. Biochim Biophys Acta. 1997 Jul 17;1353(1):50-60.