[CAS NO. 130-15-4] 1,4-Naphthoquinone

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [130-15-4]

Catalog

HY-W015490

Brand

MCE

CAS

130-15-4

DESCRIPTION [130-15-4]

Overview

MDL	-
Molecular Weight	158.16
Molecular Formula	C10H6O2
SMILES	O=C1C=CC(C2=C1C=CC=C2)=O

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]Int J Biol Macromol. 2021 Apr 24.

Summary

1,4-Naphthoquinone is a potential pharmacophore for inhibition of both MAO (monoamine oxidase) and DNA topoisomerase activities, this latter associated with antitumor activity ^[1] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 632.27 mM ; Need ultrasonic)

H ₂ O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.3227 mL	31.6136 mL	63.2271 mL
5 mM	1.2645 mL	6.3227 mL	12.6454 mL
10 mM	0.6323 mL	3.1614 mL	6.3227 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: 2.5 mg/mL (15.81 mM); Clear solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: 2.5 mg/mL (15.81 mM); Clear solution; Need ultrasonic

* All of the co-solvents are available by MCE.

References

[1] Coelho-Cerqueira E, et al. Beyond topoisomerase inhibition: antitumor 1,4-naphthoquinones as potential inhibitors of human monoamine oxidase. Chem Biol Drug Des. 2014 Apr;83(4):401-10.

Synonyms

1,4-Naphthalenedione

1,4-Naphthoquinone

1,4-Dihydro-1,4-diketonaphthalene

α-Naphthoquinone

1,4-Naphthylquinone

p-Naphthoquinone

NSC 113960

NSC 9583

Quino Power NQ

Quino Power NQI

1,4-Dihydronaphthalene-1,4-dione